The skin is covered in histamine receptors and reacts to the environment around it. It produces a histamine response when it comes into contact with certain foreign substances, e.g. chemicals, irritants, stinging nettles, etc., in which histamine is released at the site of histamine receptors and inflammation is created on skin. Often, the inflammation becomes itchy and when scratched, further histamine is released, causing further inflammation and a cycle begins where the symptoms become worse.

Toxaprevent absorbs histamine as well as toxic substances such as lead and mercury, which are absorbed by the body through the skin. This reduces the inflammation on the skin and allows individuals to break out of the cycle. The amount of histamine produced determines the size of the inflammation which may or may not become open i.e. oozing. As such, selection of which SKIN product depends on the inflammation.