Zeolite Clinoptilolite MANC®

Let’s talk Clinoptilolite the best Zeolite on the market! However, it just got better with the best engineered Zeolite on the market MANC® which stands for Modified Activated Natural Clinoptilolite.

Acid Reflux and Gastro-Oesophageal Reflux


Acid reflux happens when stomach contents and gastric acid travel from the stomach back up into the oesophagus to cause discomfort and pain.  

Acid reflux is a major symptom of Gastro-Oesophageal Reflux Disease (GORD/GERD). Heartburn is a symptom of acid reflux. 

It is normal for some reflux to occur after meals, as the food and drink travel down the digestive tract but this doesn’t normally cause discomfort.

Chewing breaks down the food in the mouth into small pieces. It then travels down the oesophagus into the stomach.  The gastric juices in the stomach break the food down into smaller molecules and the resulting chyme enters the small intestine for further digestion and absorption before being passed into the colon. Disruptions to this flow causes reflux.


Heartburn is the burning sensation in the middle of the chest and throat.  It is extremely common and affects up to 25% of adults in the UK.1

Other symptoms commonly associated with acid reflux, heartburn and GORD are regurgitation, difficulty swallowing (due to inflammation), feeling bloated, upper abdominal discomfort, nausea, burping, mucus, post-nasal drip and shortness of breath.

The reflux acid can often irritate the airways and make asthma and wheezing worse.


What is GORD?

Gastro-oesophageal reflux disease (GORD/GERD) is a chronic condition where the stomach contents reflux into the oesophagus regularly.

The gastric acid strips away at the lining of the oesophagus and causes it to become irritated and inflamed. If the inflammation is severe, it can lead to ulcers and other complications, such as oesophagitis, stricture formation and aspiration pneumonia, to name a few.2 .

The oesophagus can cope with a small amount of acid but the lining will get damaged with too much.  Some people are more sensitive to acid in their oesophagus than others.

Causes of reflux

The body has natural protective mechanisms in place to maintain a balanced state so that reflux doesn’t happen. These mechanisms include the lower oesophageal sphincter (LES), mucosal resistance and clearing the acid in the oesophagus. GORD develops when these protective mechanisms are overcome. This could be due to an impaired LES at rest or short term LES relaxations. It could be as a result of the acid in the oesophagus not being cleared properly and/or if the gastric contents are not emptied efficiently and in time.

Why does this happen?

As the food enters the oesophagus, the upper sphincter opens to let the food pass through and then closes. The oesophagus pushes the food down in waves.  At the lower end of the oesophagus, the lower sphincter (LES) opens to allow the food to pass into the stomach. The LES is a muscular ring which connects the oesophagus to the stomach and ensures that the food flows one way down into the stomach. 

The LES normally relaxes just before the oesophagus contracts and this allows food to pass from the oesophagus to the stomach.  At rest, the LES is normally of a higher pressure than in the stomach. For some patients with GORD they constantly have a weak, low pressure LES. This allows reflux every time the pressure in the stomach is higher.  Factors that decrease LES pressure include hormones, medications, specific foods (high fat-content meals, caffeine, alcohol) and smoking. Factors that increase the pressure in the stomach are ineffective digestion, absorption and emptying of the gastric contents, due to a non-optimal level of acid.

What is happening in the stomach?

Whether some substances are absorbed by the stomach or not depends on the pH level of the gastric contents.  At a low pH(acidic), substances are absorbed easily whereas at higher pH levels, absorption is slower. It is important that the pH level of the gastric juice remains at an optimal level for the digestive process to work properly.

Gastric juice is a mixture of water, acid, electrolytes (sodium, potassium, calcium, phosphate, sulphate and bicarbonate) and organic substances (mucus, pepsins and protein).  The content of the hydrochloric acid makes it highly acidic. Bicarbonate is produced when the acid passes from the stomach to the small intestine and this helps to immediately dilute and neutralise the acid which helps to protect the intestinal lining.

There are 6 different types of cells in the gastric mucosa which all play an important role in maintaining the pH level of the gastric juice. The cells do this by secreting essential substances such as mucus, bicarbonate, gastrin, histamine and hydrogen ions which are all needed for the process.

Of the 6 different types of cells, the most important ones are the parietal cells because of their acid secreting ability. Histamine is the primary modulator involved.  Histamine and parietal cells are essential in the regulation of acid secretion. Their ability to regulate and secrete acid plays an important role in acid reflux. Parietal cells respond to three stimulators for acid secretion and histamine is the primary one.

If the balance of chemicals is disrupted (due to foods, stress, illnesses or medication) then this can affect the pH levels. Any change in the pH affects how much acid is produced for digestion. For example, the pH level of the gastric juice will be affected by too much histamine and/or ammonia. The levels of histamine and ammonia can be the result of food, illnesses, medication, lifestyle and/or stress.

The composition of the meal also affects the rate at which the stomach empties.  Carbohydrates empty the fastest, then proteins, and fat is the slowest to empty. Some hormones, especially those released after digestion of fat, can also supress acid secretion. 

What else can help protect against GORD?

Fast and effective acid clearance in the oesophagus is an important protective mechanism against GORD.  Longer exposure to acid will injure the oesophagus more severely.

The oesophageal mucosa contains several components to help protect it from toxins. This includes the bicarbonate from saliva and secretions in the oesophagus and bicarbonate in the epithelium, which act as a buffer and help to protect.

High acid reflux, medication and certain foods can overwhelm the epithelial defence mechanism.

Acid Reflux, SIBO and H. pylori

Small Intestinal Bacterial Overgrowth (SIBO)

The small intestine only has a small number of bacteria. This small quantity must be maintained and kept low in order to avoid illnesses associated with an overgrowth.  Overgrowth of ‘bad’ bacteria in the small intestine causes irritation in the intestinal lining which affects the permeability of the intestinal wall. 

Stomach acid is produced to aid digestion and to kill pathogens before passing chyme through to the small intestine.  Low stomach acid prevents this and interferes with the gut microbiome by allowing pathogens through, which slows down digestion in the small intestine.  This results in the gastric contents being emptied more slowly which then affects the stomach acid and the vicious cycle carries on.

H. pylori Infection

According to Public Health England, one of the patient groups who should be tested for H. pylori are patients with dyspepsia.  Dyspepsia is a common group of symptoms associated with GORD.  Dyspepsia covers a range of symptoms which include upper abdominal pain/discomfort, heartburn, gastric reflux, nausea/vomiting.   

H.  pylori bacteria colonise in the stomach and increases inflammation.  It stimulates histamine producing cells and increases an enzyme that creates histamine.  In order to increase its survival rate in the stomach acid, H. pylori breaks down the urea in the stomach, into carbon dioxide and ammonia, which causes belching.  This increase of pressure in the stomach will affect the pressure balance between the stomach and oesophagus which then leads to reflux.  The H. pylori bacteria use the ammonium to survive in the gastric acid.  As the gastric juice must remain at an optimal level of acidic pH during digestion, any imbalances will have a negative impact on digestion and the balance of acid and will lead to reflux. An H. pylori infection (too acidic due to increased histamine or not acidic enough due to production of ammonium) will cause such an imbalance.


A change in diet and lifestyle can help. This includes avoiding trigger foods such as fried/fatty foods, chocolate, caffeine, alcohol, citrus, peppermint, carbonated drinks, tomatoes, garlic, onions) and eating smaller meal portions.  Avoid laying down soon after food, allowing 3 hours after food if possible.  Tight clothing and any pressure on the stomach can make reflux worse. To help with reflux in the night, go to bed with the upper body slightly raised.  Stress, smoking and certain medication can also cause reflux.  Regular exercise and reducing any excessive weight will also help.

Proton Pump Inhibitors (PPIs) and H2 blockers are often used to treat reflux.  They work by reducing the amount of acid produced in the stomach. Although they help with reflux, overuse results in reduction of stomach acid. This leads to pathogens being passed down the digestive tract and causes issues such as SIBO which in turn can affect reflux.

Excessive histamine and ammonia in the stomach affects the balance of chemicals in the gastric juice.  This leads to the inefficient production of acid and the ineffective digestion of food in the stomach. The result is reflux and other undesirable conditions and inflammation of the gut lining.

Removing excessive histamine and ammonium from the body will bring the pH of the gastric juice back to an optimal level and allow the body’s natural effective mechanisms of acid secretion to resume.

What role do MANC® particles play in helping with Acid Reflux?

MANC® (Modified Activated Natural Clinoptilolite) particles are the safest and most effective form of clinoptilolite zeolite which have the ability to bind to and eliminate histamine, ammonium and heavy metals from the body.

Toxaprevent Medi PLUS Sachets are specially formulated to target the upper digestive tract, including the oesophagus and stomach. The MANC® particles bind and remove excess histamine and ammonium, thereby optimising the pH levels of the gastric contents. The PLUS Sachets also contain calcium carbonate and magnesium carbonate which will help to relieve the symptoms of acid reflux more immediately with the soothing effect on the oesophagus and stomach.

For references and the full article, or for information on the applications of MANC® and how it could help you, please contact us on info@nhinnovations.com or on 02476 363873.


Adaptive immunity could colostrum be the key to create a balance?


Put simply, the immune system is a complex network of cells and processes within the body that defends against foreign invaders that shouldn’t be there, such as viruses, bacteria and parasites.  When functioning properly and effectively, the immune system identifies and attacks these threats, whilst distinguishing them from the body’s own healthy tissue.

The immune system can be broadly split into two categories; innate immunity and adaptive immunity. Innate immunity is what you are born with and mainly consists of barriers that keep foreign threats out – it is non-specific – and adaptive immunity is acquired immunity which is more complex than innate immunity. Adaptive immunity targets specific threats and creates antibodies to fight them once the body has processed and recognised them. Adaptive immunity then remembers this threat for possible future invasions.

Adaptive immunity is dependent on the specialised white blood cells known as lymphocytes, which are the cells responsible for the ability to distinguish and react to an almost infinite number of different foreign substances.

Lymphocytes are mainly dormant in the body until they receive the appropriate signals for action.  At any one time, an adult human has 2 x 1012 (that’s 2 trillion!) lymphocytes.  About 1% of this is in the bloodstream with the rest being concentrated in various tissues around the body, mainly in the lymphatic system. Part of the lymphatic system also lies in the lining of the intestines.


It is important to know the difference between boosting your immune system (and bringing it into balance) and an overactive immune system.  Obviously, an underactive immune system is not a good thing as it may not be effective in combatting harmful attacks.  At the other end though, an overactive immune response can also be harmful and lead to issues such as inflammation and autoimmune conditions.  Therefore, it is more important to think about keeping the immune system in balance.

As part of the adaptive immune system (the ‘attack’ team) is located in the gut lining, one way we could help our immune systems is by targeting the gut with what we eat and helping to keep it healthy so that the lining is free from any irritations, inflammations or leakiness. This will help it to function effectively and maintain the population of lymphocytes which are found in the gut.

It is a well-known fact that colostrum plays a vital role in the nourishment and protection of a new-born baby.  This is because colostrum is a complex, nutrient rich biological fluid which is loaded with immune, growth and tissue repair factors, and helps in the development of immunity.  It contains a significant quantity of complement components which act as natural anti-microbial agents that actively stimulate the maturation of a baby’s immune system. 1

Although the benefits of colostrum are so widely known, colostrum from a human mother is not readily available. So, many studies have been conducted on bovine (cow) colostrum.

Bovine colostrum is a rich source of immunoglobulins, a class of proteins present in the serum and the cells of the immune system, which function as antibodies. It’s been shown to be actively functional through the digestive tract in humans and a large number of studies have shown that bovine colostrum can prevent gastrointestinal tract infections and upper respiratory tract infections.2,3 Bovine milk and its components have clear functional effects on the human immune system and bovine immunoglobulin can bind to a wide range of pathogenic bacteria and viruses, as well as to many allergens.4


Toxaprevent Medi ACUTE Capsules contain the active ingredient MANC® (Modified and Activated Natural Clinoptilolite) which is a clean form of clinoptilolite zeolite and is patented for its ability to bind to and remove heavy metals, histamine and ammonium from the body. Studies have shown that MANC® strengthens the intestinal barrier and reduces intestinal permeability by binding to and removing inflammatory mediators including histamine.  Since part of the lymphatic system which is responsible for adaptive immunity is found in the intestinal lining, keeping the lining strong and irritation free would benefit hugely in the effectiveness of adaptive immunity.

The ACUTE Capsules have the benefit of the addition of high-quality colostrum (bovine, decaseinated) which will help with the strengthening of the immune system and bringing it back into balance.  Studies have shown that bovine colostrum has a number of similar effects in humans as breast milk, such as strengthening the immune function and help with protecting against gastrointestinal tract and respiratory tract infections.


  1. Colostrum and its benefits: a review (F.O Uruakpa, M.A.H Ismond, E.N.T Akobundu)
  2. Effects of Bovine Immunoglobulins on Immune Function, Allergy and Infection (Laurien H. Ulfman, Jeanette H. W. Leusen, Huub F. J. Savelkoul, John O. Warner and R. J. Joost van Neerven)
  3. Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children Khaled Saad, MD,a,Mohamed Gamil M. Abo-Elela, MD,b Khaled A. Abd El-Baseer, MD,b Ahmed E. Ahmed, MD,b Faisal-Alkhateeb Ahmad, MD,a Mostafa S. K. Tawfeek, MD,a Amira A. El-Houfey, PhD,c Mohamed Diab Aboul_Khair, MD,d Ahmad M. Abdel-Salam, MPharm,e Amir Abo-elgheit, MD,a Heba Qubaisy, MD,b Ahmed M. Ali, MD,a and Eman Abdel-Mawgoud, MDb
  4. Kelly GS. Bovine colostrums: a review of clinical uses. Altern Med Rev.(2003) 8:378–94. [PubMed] [Google Scholar]
  5. Rump JA, Arndt R, Arnold A, Bendick C, Dichtelmuller H, Franke M, et al. . Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clin Investig. (1992) 70:588–94. [PubMed] [Google Scholar]

Effectively detoxify mercury, histamine and ammonium using the right zeolite

Effectively detoxify mercury, histamine and ammonium using the right zeolite
Author: Gudrun Jonsson, Biopath and Author of “Gut Reaction” and “The Gut Reaction Eating Plan”

Even with a perfectly tailored diet that delivers the right nutrients in the optimal doses, the human body is continuously overburdened with environmental toxins as well as those created inside the body.  Consequently, the body needs help to eliminate toxic substances as its’ own detoxification system is pushed to the limit.

Heavy Metals

Environmental toxins such as lead, mercury, aluminium and other heavy metals affect everyone through their daily lives.  They enter the body in a variety of ways from the polluted air we breathe, tainted foods within our diet, and by being absorbed through our skin.  Once inside, the body will try to eliminate them using the liver and kidneys.

When heavy metals are released with bile into the gastrointestinal tract by the liver, and the body mistakes them for good substances due to their similarity to amino acids.  As a result, they are reabsorbed into the body with bile in the colon, to eventually be processed by the liver once again.  However, when the liver is at full capacity, it is unable to process toxins for elimination and instead sends them to other parts of the body where they can be stored in muscle, bones, and fat cells, until it is once again safe to release them for detoxification.

Heavy metals attack and damage the central nervous system, causing inflammation and a range of symptoms associated with heavy metal poisoning including memory loss, depression, fibromyalgia and chronic fatigue syndrome.  As for mercury, a particularly intrusive heavy metal, it has the ability to cross the blood brain barrier causing further neurological problems, and can trigger autoimmune diseases after causing inflammation in the body.


Histamine is released naturally within the body and has many roles to play.  It activates hydrochloric acid in the stomach, and is also released by the body during immune responses as an inflammatory mediator.  There are two causes for the existence of histamine in the body; it can either be created by the body itself, or it can enter the body exogenously through food and drink.  The release of histamine is involved in food intolerances as part of the immune response and causes many of the associated symptoms.

Although it is needed by the body, an excess amount can cause serious health problems.  It can cause inflammation wherever there is a histamine receptor in the body e.g. skin, lungs, digestive tract, brain, heart.  For this reason, it can cause a wide variety of problems including digestive issues, migraine, itching, urticaria and rashes.  These problems can come about due to excess histamine in the body.

The enzyme responsible for degrading histamine in the digestive tract, thereby stopping it from causing further symptoms, is diamine oxidase (DAO) and in the rest of the body histamine N-methyltransferase (HNMT) is responsible for degradation.  A histamine intolerance can be caused by a lack of the DAO enzyme which leads to an imbalance between histamine and DAO, and therefore leaves excess histamine in the digestive tract.  This histamine is then absorbed and put into circulation around the body where it is free to cause inflammation at the site of histamine receptors.  There, HNMT, which has a lower capacity to degrade histamine than DAO, must be used to catabolise histamine.

A DAO deficiency can be caused by a number of factors such as damage to intestinal cells, enzyme inhibition by medications, or it could be a genetic predisposition.  The problem is made worse when coupled with a histamine rich diet.  Testing for DAO levels in the blood can be a useful diagnostic tool for those suspected of histamine intolerance, but shouldn’t be relied upon solely as there is no well-established range in which DAO levels should fall to make a conclusive diagnosis, and the results can be skewed depending on the amount of histamine in the diet.


Ammonium is produced mainly in the intestines, kidneys and muscles, and is also a toxic by-product of protein digestion.  Interestingly, it is created by H. pylori as a shield from gastric acid, allowing the bacteria to survive in the stomach while it engages in histamine production.  The liver is responsible for detoxifying ammonium, after which it enters the blood in the form of urea and is expelled by the body in urine.  Excess amounts of ammonium in the body can become neurotoxic and increase the burden on the liver and kidneys, contributing to disease of these metabolic organs.

Ammonium can alter the pH level in the stomach in two ways.  First of all, if it comes into direct contact with gastric acid, the gastric acid will be neutralised as ammonium is alkaline.  This will reduce the amount of acid in the stomach and can lead to improper digestion of foods.  The food can then make its way back up the oesophagus with acid and cause heartburn.

Secondly, in order to detoxify ammonium, the liver requires bicarbonate.  Bicarbonate is produced by the parietal cells alongside hydrochloric acid, and is intended to counteract the gastric acid on a one-to-one ratio; one molecule of bicarbonate to detoxify one molecule of acid.  Instead, when ammonium levels are too high, the liver uses the bicarbonate to detoxify ammonium which leaves a shortage of bicarbonate to counteract the acid, leading to high levels of acidity in the stomach.  Acid reflux is caused once again.

Clinoptilolite (MANC®)

An effective chelator to eliminate heavy metals, histamine and ammonium is clinoptilolite, one of the most effective forms of zeolites.  However, to effectively eliminate these substances without putting a burden on the liver and kidneys, this particular zeolite must be processed correctly to activate and modify it.

Raw clinoptilolite is made of honeycomb shaped particles, each of which has ducts and cavities running through it.  The particles exhibit a negative charged which enables it to attract positively charged ions, much like a magnet.  These ions are then stored in the ducts and cavities running through the honeycomb structure.  This method of ion absorption is how clinoptilolite binds to histamine, ammonium and heavy metals.  The negative charge also means it has a higher affinity for toxic ions which have a higher positive charge, thereby enabling clinoptilolite to selectively bind to toxic substances.

Firstly, clinoptilolite must be cleansed of any toxins it has already absorbed, to both maximise surface area for absorption and to stop it from potentially adding toxins to the body, unlike crushed clinoptilolite.

Secondly, to ensure the clinoptilolite doesn’t increase the burden on the liver, only clinoptilolite which has a specific particle size can be used.  This ensures it isn’t absorbed by the body.  Anything Particles below 3 micrometres will may be absorbed by the gut, and in those with leaky gut this is slightly higher.  Therefore, the clinoptilolite particle should be between 6 – 10 micrometres (thousandth of a mm) to absorb the maximum amount of toxins in the gut without passing through the stomach or intestinal wall.  Instead, processed clinoptilolite binds toxins in the gastrointestinal tract and is directly eliminated via natural bowel movements.  This reduces the toxic burden on the liver, giving it more capacity to do its job as a metabolic organ.

Tests simulating the digestive tract show that correctly processed clinoptilolite can bind 45% of mercury, 94% of histamine and 85% of ammonium, and reports have shown that this highly safe way of detoxifying the body is not detrimental to the balance of micronutrients in the body.

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