Effectively detoxify mercury, histamine and ammonium using the right zeolite

Effectively detoxify mercury, histamine and ammonium using the right zeolite
Author: Gudrun Jonsson, Biopath and Author of “Gut Reaction” and “The Gut Reaction Eating Plan”

Even with a perfectly tailored diet that delivers the right nutrients in the optimal doses, the human body is continuously overburdened with environmental toxins as well as those created inside the body.  Consequently, the body needs help to eliminate toxic substances as its’ own detoxification system is pushed to the limit.

Heavy Metals

Environmental toxins such as lead, mercury, aluminium and other heavy metals affect everyone through their daily lives.  They enter the body in a variety of ways from the polluted air we breathe, tainted foods within our diet, and by being absorbed through our skin.  Once inside, the body will try to eliminate them using the liver and kidneys.

When heavy metals are released with bile into the gastrointestinal tract by the liver, and the body mistakes them for good substances due to their similarity to amino acids.  As a result, they are reabsorbed into the body with bile in the colon, to eventually be processed by the liver once again.  However, when the liver is at full capacity, it is unable to process toxins for elimination and instead sends them to other parts of the body where they can be stored in muscle, bones, and fat cells, until it is once again safe to release them for detoxification.

Heavy metals attack and damage the central nervous system, causing inflammation and a range of symptoms associated with heavy metal poisoning including memory loss, depression, fibromyalgia and chronic fatigue syndrome.  As for mercury, a particularly intrusive heavy metal, it has the ability to cross the blood brain barrier causing further neurological problems, and can trigger autoimmune diseases after causing inflammation in the body.


Histamine is released naturally within the body and has many roles to play.  It activates hydrochloric acid in the stomach, and is also released by the body during immune responses as an inflammatory mediator.  There are two causes for the existence of histamine in the body; it can either be created by the body itself, or it can enter the body exogenously through food and drink.  The release of histamine is involved in food intolerances as part of the immune response and causes many of the associated symptoms.

Although it is needed by the body, an excess amount can cause serious health problems.  It can cause inflammation wherever there is a histamine receptor in the body e.g. skin, lungs, digestive tract, brain, heart.  For this reason, it can cause a wide variety of problems including digestive issues, migraine, itching, urticaria and rashes.  These problems can come about due to excess histamine in the body.

The enzyme responsible for degrading histamine in the digestive tract, thereby stopping it from causing further symptoms, is diamine oxidase (DAO) and in the rest of the body histamine N-methyltransferase (HNMT) is responsible for degradation.  A histamine intolerance can be caused by a lack of the DAO enzyme which leads to an imbalance between histamine and DAO, and therefore leaves excess histamine in the digestive tract.  This histamine is then absorbed and put into circulation around the body where it is free to cause inflammation at the site of histamine receptors.  There, HNMT, which has a lower capacity to degrade histamine than DAO, must be used to catabolise histamine.

A DAO deficiency can be caused by a number of factors such as damage to intestinal cells, enzyme inhibition by medications, or it could be a genetic predisposition.  The problem is made worse when coupled with a histamine rich diet.  Testing for DAO levels in the blood can be a useful diagnostic tool for those suspected of histamine intolerance, but shouldn’t be relied upon solely as there is no well-established range in which DAO levels should fall to make a conclusive diagnosis, and the results can be skewed depending on the amount of histamine in the diet.


Ammonium is produced mainly in the intestines, kidneys and muscles, and is also a toxic by-product of protein digestion.  Interestingly, it is created by H. pylori as a shield from gastric acid, allowing the bacteria to survive in the stomach while it engages in histamine production.  The liver is responsible for detoxifying ammonium, after which it enters the blood in the form of urea and is expelled by the body in urine.  Excess amounts of ammonium in the body can become neurotoxic and increase the burden on the liver and kidneys, contributing to disease of these metabolic organs.

Ammonium can alter the pH level in the stomach in two ways.  First of all, if it comes into direct contact with gastric acid, the gastric acid will be neutralised as ammonium is alkaline.  This will reduce the amount of acid in the stomach and can lead to improper digestion of foods.  The food can then make its way back up the oesophagus with acid and cause heartburn.

Secondly, in order to detoxify ammonium, the liver requires bicarbonate.  Bicarbonate is produced by the parietal cells alongside hydrochloric acid, and is intended to counteract the gastric acid on a one-to-one ratio; one molecule of bicarbonate to detoxify one molecule of acid.  Instead, when ammonium levels are too high, the liver uses the bicarbonate to detoxify ammonium which leaves a shortage of bicarbonate to counteract the acid, leading to high levels of acidity in the stomach.  Acid reflux is caused once again.

Clinoptilolite (MANC®)

An effective chelator to eliminate heavy metals, histamine and ammonium is clinoptilolite, one of the most effective forms of zeolites.  However, to effectively eliminate these substances without putting a burden on the liver and kidneys, this particular zeolite must be processed correctly to activate and modify it.

Raw clinoptilolite is made of honeycomb shaped particles, each of which has ducts and cavities running through it.  The particles exhibit a negative charged which enables it to attract positively charged ions, much like a magnet.  These ions are then stored in the ducts and cavities running through the honeycomb structure.  This method of ion absorption is how clinoptilolite binds to histamine, ammonium and heavy metals.  The negative charge also means it has a higher affinity for toxic ions which have a higher positive charge, thereby enabling clinoptilolite to selectively bind to toxic substances.

Firstly, clinoptilolite must be cleansed of any toxins it has already absorbed, to both maximise surface area for absorption and to stop it from potentially adding toxins to the body, unlike crushed clinoptilolite.

Secondly, to ensure the clinoptilolite doesn’t increase the burden on the liver, only clinoptilolite which has a specific particle size can be used.  This ensures it isn’t absorbed by the body.  Anything Particles below 3 micrometres will may be absorbed by the gut, and in those with leaky gut this is slightly higher.  Therefore, the clinoptilolite particle should be between 6 – 10 micrometres (thousandth of a mm) to absorb the maximum amount of toxins in the gut without passing through the stomach or intestinal wall.  Instead, processed clinoptilolite binds toxins in the gastrointestinal tract and is directly eliminated via natural bowel movements.  This reduces the toxic burden on the liver, giving it more capacity to do its job as a metabolic organ.

Tests simulating the digestive tract show that correctly processed clinoptilolite can bind 45% of mercury, 94% of histamine and 85% of ammonium, and reports have shown that this highly safe way of detoxifying the body is not detrimental to the balance of micronutrients in the body.

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