Stress, pathogens, medications, poor diets – often high in lectins such as wheat agglutinin – and toxic substances all contribute towards increased intestinal permeability which is measured using zonulin levels as an indicator. When faced with these factors, the intestinal tract reacts with a histamine response that creates inflammation in the lining of the gut and the epithelial tight junctions are compromised, causing the gut to become leaky. This inflammation acts a barrier and reduces the absorption of nutrition – a form of starvation – whilst the loosened tight junctions allow for the passage of unchecked particles, pathogens, lipopolysaccharides and food proteins into the body.
As a result, the body initiates an immune response resulting in a wide variety of symptoms – the more permeable the gut, the bigger the reaction. Unwanted food proteins that are absorbed mimic certain body tissues, provoking an attack from the immune system (causing histamine reactions and inflammation) not only on the protein, but also on bodily tissues that contain similar proteins. As such, the body begins attacking itself and the immune systems’ regulatory T cells cease to suppress the immune system which becomes hyperactive. In addition, opportunistic bugs such as candida thrive with a leaky gut, and disturb the balance of gut bacteria.
Toxaprevent exerts an anti-inflammatory effect on the intestinal tract by binding and removing histamine in the wall of the small intestine. This reduces the inflammation and allows the epithelial tight junctions a chance to repair themselves, strengthening the integrity of the intestinal barrier. Consequently, nutrition is better absorbed and harmful substances are correctly modulated by zonulin and kept in the intestinal lumen, rather than being absorbed, so the immune system will not react to them. This effect was shown in a study which saw zonulin levels decrease over a 3 month supplementation period using MANC®. Colostrum (decaseinated) is also added to the ACUTE Capsules to help rebalance the immune system.