Why is it important to have low levels of ammonium?

Ammonium is a toxic substance when it exists in excess amounts in the body. Low levels of ammonium are healthy as this contributes to balancing the body’s natural pH level, however high levels of ammonium can become toxic to the body.

High levels of ammonium production can contribute to poor health as the liver and kidneys will need to work harder to clear excess ammonium from the body. In cases where the liver is already overburdened and functioning poorly, the liver may be unable to effectively detoxify ammonium, causing an excess amount of ammonium. Excess ammonium can become toxic to the brain and nervous system, and can contribute to a feeling of lethargy, being unwell and brain fog, as well as further diminishing the functionality of the liver and kidneys. High levels of ammonium in the body can also be a contributing factor to dementia and other mental illnesses.

Many of the illnesses caused by high ammonium levels in the body are chronic and untreatable, so the safest course of action is to protect your liver and kidneys to avoid damage to them. 

In addition, the liver will take the important substance bicarbonate, which is produced to counteract stomach acid, from the stomach through the portal vein and uses it to detoxify ammonium in the liver. High ammonium levels mean more bicarbonate is taken which leaves less bicarbonate to counteract stomach acid in the stomach. This can result in high levels of stomach acid and acid reflux symptoms.

Regular use with Toxaprevent will bind and remove excess ammonium from the digestive tract, meaning the liver and kidneys will not have to bear the burden of any ammonium carried out of the system with MANC® particles.

Is ammonium produced in other ways?

Ammonium can be produced in the digestive tract through several mechanisms. One of the most common ways is through bacteria which produce the urease enzyme. The urease enzyme has the ability to break down urea, a substance which is present in throughout the digestive tract, and splits urea into carbon dioxide and ammonia (ammonia is the non-ionic form of ammonium). In order for ammonia to be converted into ammonium, it needs an extra hydrogen atom which it can gain from acid e.g. stomach acid. 

H. pylori, for example, affects an estimated 50% of the population and is a bacterial infestation of the stomach which creates the urease enzyme to convert urea into carbon dioxide and ammonia. The ammonia is then used as a ‘shield’ to protect itself from being killed by stomach acid as it neutralise stomach acid. When this happens, the stomach acid donates a hydrogen atom to ammonia and turns ammonia into ammonium, a positively charged ion which MANC® particles can bind to.

Lower down in the intestinal tract, bacteria such as also produce the urease enzyme, releasing ammonia from urea in the colon. Simultaneously, certain anaerobic bacteria such as bacteroides, bifidobacterium, aspergillus, ruminococcus, peptostreptococcus, fusobacterium, lactobacillus, streptococcus play a role in fermenting dietary fibres to create short chain fatty acids such as acetate, propionate, and butyrate, which contain the hydrogen atom. This provides the necessary conditions for protonation to occur whereby ammonia takes up a hydrogen atom from the short chain fatty acids and converts into ammonium. This process is known as protonation.

Why does the body produce ammonium?

Ammonium is a natural by-product of protein digestion, which is broken down by the liver and expelled from the body via the kidneys. Maintaining a low level of ammonium is important as it helps to reduce the toxic burden on the liver, thereby helping to optimise liver function.

What exactly are MANC® particles (the active ingredient in all Toxaprevent products)?

MANC® particles are derived from correctly processing clinoptilolite zeolite to ensure they are safe enough eliminate heavy metals, histamine and ammonium from the body safely. In order for clinoptilolite zeolite to be safe for human consumption it must cleansed of any and all toxins it has already absorbed (from the ground it was taken from) and it must stay only in the digestive tract. MANC® particles are produced once the clinoptilolite zeolite has been cleansed and the size of the particles are between 6 – 10 microns – this is how MANC® particles are produced.

Froximun AG are the only company in the world which produces MANC® particles, the gold standard of zeolite.

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