Does Toxaprevent bind to mycotoxins/mold?

MANC® particles have been shown to bind to mycotoxins released from mold and fungus. This is due to their silica content. 

Mold and fungal infections use mycotoxins in order to spread and thrive. Not only do MANC® particles bind to mycotoxins in order to reduce their ability to spread, but they also restore the integrity of the gut barrier (i.e. leaky gut) by binding to histamine and reducing inflammation in the intestinal lining. This allows the epithelial tight junctions to repair themselves. The combined effect is that MANC® particles reduce the ability of mold and fungal infections to spread, while changing the environment in the intestinal tract to make it unfavourable for mold and fungal infections to thrive. This makes it easier to tackle mold and fungal infections.

How should I use Toxaprevent for a heavy metals cleanse?

ake 2 PURE Capsules three times a day with food and with at least 200ml water. Do this for at least 3 – 6 months.

As food passes from the stomach into the small intestine bile is released from the gall bladder and into the small intestine. Digestive enzymes contained in bile help break down the food. However, bile also contains heavy metals and other toxic substances which are intended for elimination via natural bowel movements. Therefore, taking the PURE Capsules with food presents the best opportunity for MANC® particles to bind heavy metals released with bile in the small intestinal tract, ensuring that, once bound to MANC® particles, heavy metals are also eliminated via natural bowel movements. This prevents them from being reabsorbed in the large colon. Taking the PURE Capsules in this manner will bind and eliminate heavy metals which are in enterohepatic circulation and can trigger the release of heavy metals stored in the body.

If heavy metals are present in the upper GI i.e. the mouth, oesophagus, and stomach, then the PLUS Sachets can be used as these are mixed in water and drank, allowing MANC® particles to act immediately, binding heavy metals from the mouth onwards and ensuring their removal from the body via natural bowel movements. 

1 PLUS Sachet can be taken in the morning and 1 more PLUS Sachet can be taken at night. The PLUS Sachets can be taken alongside the PURE Capsules to ensure heavy metals in the entire digestive tract are being bound and eliminated by MANC® particles.

If heavy metals are present in the mouth, Toxaprevent DENTURA MED toothpaste can also be used each morning to target these heavy metals.

Why is it important to have low levels of ammonium?

Ammonium is a toxic substance when it exists in excess amounts in the body. Low levels of ammonium are healthy as this contributes to balancing the body’s natural pH level, however high levels of ammonium can become toxic to the body.

High levels of ammonium production can contribute to poor health as the liver and kidneys will need to work harder to clear excess ammonium from the body. In cases where the liver is already overburdened and functioning poorly, the liver may be unable to effectively detoxify ammonium, causing an excess amount of ammonium. Excess ammonium can become toxic to the brain and nervous system, and can contribute to a feeling of lethargy, being unwell and brain fog, as well as further diminishing the functionality of the liver and kidneys. High levels of ammonium in the body can also be a contributing factor to dementia and other mental illnesses.

Many of the illnesses caused by high ammonium levels in the body are chronic and untreatable, so the safest course of action is to protect your liver and kidneys to avoid damage to them. 

In addition, the liver will take the important substance bicarbonate, which is produced to counteract stomach acid, from the stomach through the portal vein and uses it to detoxify ammonium in the liver. High ammonium levels mean more bicarbonate is taken which leaves less bicarbonate to counteract stomach acid in the stomach. This can result in high levels of stomach acid and acid reflux symptoms.

Regular use with Toxaprevent will bind and remove excess ammonium from the digestive tract, meaning the liver and kidneys will not have to bear the burden of any ammonium carried out of the system with MANC® particles.

Is ammonium produced in other ways?

Ammonium can be produced in the digestive tract through several mechanisms. One of the most common ways is through bacteria which produce the urease enzyme. The urease enzyme has the ability to break down urea, a substance which is present in throughout the digestive tract, and splits urea into carbon dioxide and ammonia (ammonia is the non-ionic form of ammonium). In order for ammonia to be converted into ammonium, it needs an extra hydrogen atom which it can gain from acid e.g. stomach acid. 

H. pylori, for example, affects an estimated 50% of the population and is a bacterial infestation of the stomach which creates the urease enzyme to convert urea into carbon dioxide and ammonia. The ammonia is then used as a ‘shield’ to protect itself from being killed by stomach acid as it neutralise stomach acid. When this happens, the stomach acid donates a hydrogen atom to ammonia and turns ammonia into ammonium, a positively charged ion which MANC® particles can bind to.

Lower down in the intestinal tract, bacteria such as also produce the urease enzyme, releasing ammonia from urea in the colon. Simultaneously, certain anaerobic bacteria such as bacteroides, bifidobacterium, aspergillus, ruminococcus, peptostreptococcus, fusobacterium, lactobacillus, streptococcus play a role in fermenting dietary fibres to create short chain fatty acids such as acetate, propionate, and butyrate, which contain the hydrogen atom. This provides the necessary conditions for protonation to occur whereby ammonia takes up a hydrogen atom from the short chain fatty acids and converts into ammonium. This process is known as protonation.

Why does Froximun AG have a responsible person?

Froximun AG, the manufacturers of Toxaprevent, are obliged to have a dedicated responsible person as part of their quality control system who, in the unlikely case that an individual has an adverse reaction to MANC® particles, can be contacted to record the adverse event and seek further advice from their expert medical service. This is put in place as a measure for the safety and protection of those taking Toxaprevent.  

Food supplements containing clinoptilolite zeolite do not have a responsible person who can be contacted in the case of adverse reactions. See ‘Are other zeolites as safe and as effective as MANC® particles? for more information on what makes a zeolite product safe for human consumption.

Why are MANC® particles classified as a medical device?

MANC® particles do not have a physiological, pharmacological or immunological effect on the body. They are inert and work by using a physical mechanism (ion exchange) to safely bind toxic substances whist travelling through the digestive tract and are eventually passed out of the body through natural bowel movements. As such, MANC® particles do not interfere with the body’s physiological processes, nor is it absorbed by the body, and this is the main reason as to why it has been successfully registered as a medical device.

Can MANC® particles break down in acid and poison me with aluminium like other clinoptilolite zeolite products do?

No. MANC® particles will not break down in stomach acid and will not poison you.

To ensure your safety as a user, MANC® particles and the Toxaprevent medical devices developed from them went through all product tests and analyses to assess safety and biocompatibility (even before the products were brought onto the market as certified medical devices)

Above all, the possible exposure to aluminium was investigated, since the MANC® particle is an alumino-silicate. Lead was also examined because it is an endogenous trace component found in clinoptilolite.

These tests go through several stages before the products are released, processed and placed on the market.

A comprehensive evaluation of data from clinical studies, and in vitro and in vivo investigations with the raw materials and products showed that the products based on MANC® particles are safe.

The form of the products has been tested by various test bodies, independent doctors, biochemists and medical assessors in the form of biocompatibility tests in accordance with the EN ISO 10993 series and this was confirmed again in 2019.

Toxicity tests:

• Testing the cytotoxicity according to EN ISO 10993-5: 2009 (GLP mode). Result: not cell-toxic, does not lead to any biological-toxicological damage to the test cells

• Tests for systemic toxicity (acute) according to EN ISO 10993-11: 2009. Result: no systemic toxicity.


• Studies showed that the endogenous aluminum and lead components are not removed and therefore not absorbed through the intestine. This has been demonstrated by absorption tests under clinical observation on the human body.

• Clinical studies showed that clinical chemistry and hematology, and mineral status of users did not change.

Further pre clinical research showed that clinoptilolite:

• can bind heavy metals such as lead in vitro in a simulated gastrointestinal environment

• caused a decrease in aluminum concentrations in the plasma, liver and bones of animals poisoned with aluminum

• in the mouse model, can reduce cytotoxicity caused by lead and the lead concentration in the organism decreased.

Other quality features to completely rule out unlikely residual risks:

• Use of gastro-resistant capsules (Medi PURE and Medi ACUTE), which consists of harmless fiber (HPMC, gellan). This avoids the interaction of MANC® particles with gastric acid, which completely prevents the removal of trace elements in an acidic environment.

• The second measure is to add pH-increasing additives, such as calcium carbonate and magnesium carbonate, to the MANC® particles in Medi PLUS Sachets, allowing for passage through the gastric acid without the need for enteric-coated capsules. The same applies to the admixtures of HALISTOP® Chewable Tablets.

The structure of clinoptilolite zeolite is made from aluminium and silica and it is known that this structure breaks down and releases aluminium in stomach acid. All products containing clinoptilolite must therefore be specifically formulated and prepared to ensure aluminium is not released from the structure of clinoptilolite particles.

Unlike other clinoptilolite products, MANC® particles will not break down and will not release aluminium into the body

Toxaprevent PLUS Sachets have added magnesium carbonate and calcium carbonate to increase the pH level of stomach, thereby reducing the acidity in the stomach. This ensures that the stomach acid is not acidic enough to break MANC® particles, and allows them to reach the intestinal tract safely and intact. The pH level in the intestinal tract is too high to break the particle down so aluminium will not be released from the particle. Similarly, the HALISTOP® Chewable Tablets contain ad-mixtures which increase the pH of the stomach to allow for the safe passage of MANC® particles into the intestinal tract without poisoning the body with aluminium.

MANC® particles in capsule form (PURE and ACUTE Capsules) completely by-pass the stomach acid due to the gastro-resistant capsules used. The capsules allow MANC® particles to completely avoid acid in the stomach and only open in the intestinal tract where the acidity level is too high to break MANC® particles down.

In vivo and in vitro studies have proved this. The aluminium levels in long-term users of products containing MANC® particles (Toxaprevent) as well as the aluminium content of the MANC® particles were checked. Patients were given MANC® particles in their various forms. Stool samples were collected and analysed, and showed that the aluminium content of MANC® was higher after it had been excreted, meaning that MANC® particles were in fact binding and removing aluminium from the body, and was not poisoning the body with aluminium. All patients reported undetectable levels of aluminium after using MANC® particles for various periods of time. MANC® is completely safe to use with no risk of aluminium poisoning.

As such, any products containing clinoptilolite must meet the rigorous high standards which MANC® particles meet in order to be considered safe for human consumption and to avoid poisoning with aluminium from clinoptilolite. This is just one of the many reasons why MANC® particles are the safest form of clinoptilolite zeolite available today.

Why do clinoptilolite zeolite, including MANC® particles, need to be vacuum sealed in blister packs and sachets?

For safety and effectiveness, all clinoptilolite zeolite products, including MANC® particles, need to be vacuum sealed in air tight sachets or capsules. 

Clinoptilolite zeolite will immediately bind to toxins in the air as soon as they opened from their packaging and exposed to the air, causing contamination. Each time clinoptilolite zeolite is exposed to the air presents another opportunity for clinoptilolite zeolite to bind to more toxins. These toxins take up some of the ‘cages’ in clinoptilolite (reducing its ability to uptake harmful substances in the body) and may poison the body upon consumption of clinoptilolite zeolite – defeating the purpose of taking clinoptilolite in the first place i.e. to detoxify the body of harmful substances and not add to it. This means that clinoptilolite zeolite products which are not vacuum sealed may not be safe for human consumption because the unwanted toxins they absorb from the air could begin to poison the body and reduce their effectiveness. 

Each dose of MANC® particles is packaged in vacuum sealed sachets and blister packs to ensure that the time allowed for contamination with toxins in the air is absolutely minimal. This allows you to open one full dose immediately before you need to take it and consume right away without having to open and store the rest of the MANC® particles – instead of having to scoop it out of a tub and then reseal. This means MANC® particles keep their safety and efficacy.

Why shouldn’t clinoptilolite zeolite ever be absorbed into the body and metabolised by the liver or kidneys?

Clinoptilolite zeolite particles should never be absorbed into the body. The body usually deals with particles taken in through the mouth (usually particles carried in with food) by keeping them in the intestinal tract where they are unable to cross the intestinal barrier into the body. Particles are then eliminated via natural bowel movements. Although smaller particles (those under 3 microns and including nano sized particles) of clinoptilolite are more favourable (because they have a larger surface area which allows them to absorb more toxic substances than larger particles), these are too small as they can be absorbed through the intestinal barrier and into the body. The liver and kidneys will then be tasked with the job of removing them from the body which will be difficult because the body doesn’t have a detoxification pathway for particles once they are absorbed into the body. Transporting these small clinoptilolite particles around the body could potentially lead to ‘clogging up’ of particles in various parts of the body such as the kidneys or gall bladder, and can further contribute to ill health and a feeling of being unwell.

Our metabolic organs are usually already over-worked and over-burdened with daily toxins from the food we eat, pollution, and toxic substances created within the body – any small clinoptilolite particles will only add to the workload. It is therefore important that clinoptilolite particles stay within the digestive tract and are not absorbed by the body. MANC® particles achieve this by ensuring that the particle size is small enough to bind as many toxic substances as possible (for maximum effectiveness) whilst being too large to pass through the intestinal barrier. In other words, MANC® particles are optimal in size.

Although smaller clinoptilolite particles may bind toxins that are stored in the body (in fats, muscles, etc.), getting them back out of the body is difficult, and potentially dangerous! This is why MANC® particles only stay in the digestive tract – because this is the only part of the body that is adequately equipped to eliminate particles. As a result, toxins bound by MANC® particles in the digestive tract are removed via bowel movements, instead of being absorbed. This means that the liver and kidneys are relieved of their daily toxic burden and can function more effectively to handle daily toxins. 

Why is it important to keep MANC® particles between 6-10 microns?

In vivo studies on MANC® have shown that particles over 6 microns (one micron is one thousandth of a millimetre) are not absorbed by the body and therefore cannot further burden the liver and kidneys. This is important as zeolite particles below 6 microns size may enter the body, which could cause severe detox reactions as well as placing a further burden on the liver and kidneys. Given that these metabolic organs are usually already over-burdened, if small zeolite particles under 6 microns were to enter the system and bind to stored toxins (stored in fat, muscle or bone, etc.), these zeolite particles would eventually need to be removed from the body via the liver and kidney, at which point those toxins could potentially be deposited into the liver and kidney. Therefore, the liver and kidneys will need to eliminate not only the small zeolite particles, but also the toxins it will carry.

MANC® particles are also limited to a maximum particle size of 10 microns. This ensures essential minerals and micronutrients are not bound by MANC® particles. Zeolite particles above 10 microns can bind to essential minerals and micronutrients and can deplete them from the body. 

This is why optimising MANC® particles between 6-10 microns is vital. The result is that MANC® particles selectively bind to only toxic substances in the body, and actually reduces the toxic burden on the liver and kidneys, making MANC® the safest zeolite to use.

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